OKY-1581-药物合成数据库

【药物名称】OKY-1581

化学结构式(Chemical Structure):

参考文献No.	701318
标题:	Pyridine derivatives
作者:	Tanouchi, T.; et al.
来源:	DE 2951786; FR 2445319; FR 2510108; GB 2039903; US 4271170; US 4317828

合成路线图解说明: The reaction of 3-chloromethylpyridine (I) with the Grignard reagent of 4-bromobenzaldehyde diethylacetal (II) in THF gives 4-(3-pyridylmethyl)benzaldehyde diethylacetal (III), which is hydrolyzed with aqueous 1N HCl to 4-(3-pyridylmethyl)benzaldehyde (IV). The Wittig condensation of (IV) with 1-(ethoxycarbonyl)ethylidenetriphenylphosphorane (V) in CHCl3 affords 3-[4-(3-pyridylmethyl)phenyl]-2-methylacryl ic acid ethyl ester (VI), which is finally hydrolyzed with aqueous NaOH.

参考文献No.	800407
标题:	OKY-1581
作者:	Hillier, K.; Serradell, M.N.; Blancafort, P.; Casta馿r, J.
来源:	Drugs Fut 1982,7(6),399

合成路线图解说明: The reaction of 3-chloromethylpyridine (I) with the Grignard reagent of 4-bromobenzaldehyde diethylacetal (II) in THF gives 4-(3-pyridylmethyl)benzaldehyde diethylacetal (III), which is hydrolyzed with aqueous 1N HCl to 4-(3-pyridylmethyl)benzaldehyde (IV). The Wittig condensation of (IV) with 1-(ethoxycarbonyl)ethylidenetriphenylphosphorane (V) in CHCl3 affords 3-[4-(3-pyridylmethyl)phenyl]-2-methylacryl ic acid ethyl ester (VI), which is finally hydrolyzed with aqueous NaOH.