Sofalcone, Solon-药物合成数据库

【药物名称】Sofalcone, Solon

化学结构式(Chemical Structure):

参考文献No.	47222
标题:	2-(Carboxymethoxy)chalcones
作者:	Kyogoku, K.; Hatayama, K.; Yokomori, S.; Sawada, J.; Tanaka, I. (Taisho Pharmaceutical Co., Ltd.)
来源:	DE 2705603; ES 455620; FR 2340924; GB 1523241; JP 52097950; US 4085135

合成路线图解说明: The reaction of 2-hydroxy-4-(3-methyl-2-butenyloxy)acetophenone (I) with ethyl bromoacetate (II) by means of KOH in acetone gives 2-ethoxycarbonylmethoxy-4-(3-methyl-2-butenyloxy)acetophenone (III), which is then condensed with 4-(3-methyl-2-butenyloxy)benzaldehyde (IV) by means of KOH in ethanol.

参考文献No.	800357
标题:	SU-88
作者:	Grau, M.; Casta馿r, J.; Blancafort, P.; Serradell, M.N.
来源:	Drugs Fut 1983,8(6),513

合成路线图解说明: The reaction of 2-hydroxy-4-(3-methyl-2-butenyloxy)acetophenone (I) with ethyl bromoacetate (II) by means of KOH in acetone gives 2-ethoxycarbonylmethoxy-4-(3-methyl-2-butenyloxy)acetophenone (III), which is then condensed with 4-(3-methyl-2-butenyloxy)benzaldehyde (IV) by means of KOH in ethanol.