【药物名称】Netilmicin sulfate, Sch-20569, Certomycin, Zetamicin, Netillin, Netromicine, Netromycin
化学结构式(Chemical Structure):
参考文献No.47030
标题:Novel pseudotrisaccharides and methods for their production
作者:Daniels, P.J.L.; Testa, R.; Tattanahalli, L.; Mallams, A.K.; Wright, J.J.; Weinstein, M.J.; Wagman, G.H. (Schering Corp.)
来源:DE 2437160; FR 2240015; GB 1473733; US 4029882
合成路线图解说明:

By alkylation of sisomicin (I) with acetaldehyde (II) and sodium cyanoborohydride in water with some sulfuric acid.

合成路线图解说明:

The reaction of gentamicin B sulfate (betamicin sulfate) (I) with N-(S-3-benzyloxycarbonylamino)-2-hydroxypropionylsuccinimide (II) by means of triethylamine in water-methanol-DMF gives 1-N-(S-3-benzyloxycarbonylamino-2-hydropropionyl)betamicin (III), which is finally hydrogenated with H2 over Pd/C in methanol-water.

参考文献No.614025
标题:Synthesis of 1-N-ethylsisomicin: a broad-spectrum semisynthetic aminoglycoside antibiotic
作者:Wright, J.J.
来源:J Chem Soc Chem Commun 1976,(6),206-208
合成路线图解说明:

By alkylation of sisomicin (I) with acetaldehyde (II) and sodium cyanoborohydride in water with some sulfuric acid.

参考文献No.614694
标题:Netilmicin
作者:Casta馿r, J.; Loren, J.G.
来源:Drugs Fut 1978,3(7),527
合成路线图解说明:

By alkylation of sisomicin (I) with acetaldehyde (II) and sodium cyanoborohydride in water with some sulfuric acid.

参考文献No.659674
标题:An efficient and selective 1-N-monoethylation of sisomicin: Process development of netilmicin
作者:Nam, G.; et al.
来源:Org Process Res Dev 2002,6(1),78
合成路线图解说明:

The selective triacetylation of sisomicin (I) with zinc acetate, acetic anhydride and TEA in methanol/THF gives the triacetate (II), which is then alkylated with acetic acid and NaBH4 in chloroform, affording 1-N-ethyl-3,2',6'-tri-N-acetylsisomicin (III). Finally, this compound is deacetylated by means of refluxing aqueous NaOH.

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