Tolciclate, K-9147-药物合成数据库

【药物名称】Tolciclate, K-9147

化学结构式(Chemical Structure):

参考文献No.	800737
标题:	Tolciclate
作者:	Casta馿r, J.; de Angelis, L.
来源:	Drugs Fut 1976,1(11),543

合成路线图解说明: Compound can be prepared in two different ways both starting from sodium 1,4-methano-1,2,3,4-tetrahydro-6-naphthoxide (I): 1) The reaction of (I) with thiophosgene in chloroform gives O-(1,4-methano-1,2,3,4-tetrahydro-6-naphthyl)chlorothioformiate (II), n(20 C)(D) = 1.5930, which is then condensed with N-methyl-m-toluidine in the same solvent. 2) The condensation of (I) with N-methyl-N-(m-tolyl)thiocarbamoyl chloride (III) in acetone.

参考文献No.	800738
标题:	Tetrahydro-2-naphthyl ester derivatives of tinonocarbanilic acids
作者:	Melloni, P.; et al.
来源:	DE 2313845; FR 2181835; GB 1364407; JP 49005955; US 3855263

合成路线图解说明: Compound can be prepared in two different ways both starting from sodium 1,4-methano-1,2,3,4-tetrahydro-6-naphthoxide (I): 1) The reaction of (I) with thiophosgene in chloroform gives O-(1,4-methano-1,2,3,4-tetrahydro-6-naphthyl)chlorothioformiate (II), n(20 C)(D) = 1.5930, which is then condensed with N-methyl-m-toluidine in the same solvent. 2) The condensation of (I) with N-methyl-N-(m-tolyl)thiocarbamoyl chloride (III) in acetone.