【药物名称】Felodipine, H-154/82, CGH-869, Prevex, Perfudal, Lexxel(Comb. with enalapril), Logimax, Splendil, Munobal, Modip, Flodil, Plendil, Hydac
化学结构式(Chemical Structure):
参考文献No.45192
标题:2,6-Dimethyl-4-2,3-disubstituted phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid-3,5-asymmetric diesters having hypotensive properties, as well as method for treating hypertensive conditions and pharmaceutical preparations containing same
作者:Bernston, P.B.; Carlsson, S.A.I.; Gaarder, J.O.; Ljung, B.R. (AstraZeneca AB)
来源:CA 1117530; EP 0007293; JP 55009083; US 4264611
合成路线图解说明:

By cyclization of methyl 2,3-dichlorobenzyldeneacetoacetate (I) with ethyl 3-aminocrotonate (II) in tert-butanol at room temperature.

合成路线图解说明:

By cyclization of 2,3-dichlorobenzaldehyde (I) with 3-aminocrotonic acid ethyl ester (II) and acetylacetic acid methyl ester (III) in refluxing ethanol.

合成路线图解说明:

By cyclization of 2-(2,3-dichlorobenzylidene)acetyl acetic acid methyl ester (IV) with acetylacetic acid ethyl ester (V) and ammonia (VI) in tert-butanol.

参考文献No.62321
标题:Felodipine
作者:Blancafort, P.; Serradell, M.N.; Sneddon, J.M.; Casta馿r, J.
来源:Drugs Fut 1982,7(3),160
合成路线图解说明:

By cyclization of methyl 2,3-dichlorobenzyldeneacetoacetate (I) with ethyl 3-aminocrotonate (II) in tert-butanol at room temperature.

参考文献No.800184
标题:Determination of te conformation of felodipine by 1H NMR-spinlattice relaxation time measurements
作者:Carter, R.E.; Berntsson, P.
来源:Acta Pharm Suec 1981,18221-226
合成路线图解说明:

By cyclization of methyl 2,3-dichlorobenzyldeneacetoacetate (I) with ethyl 3-aminocrotonate (II) in tert-butanol at room temperature.

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