Tampramine fumarate, AHR-9377-药物合成数据库

【药物名称】Tampramine fumarate, AHR-9377

化学结构式(Chemical Structure):

参考文献No.	46553
标题:	Pyridol [1,4] benzodiazepines phenyl-substituees et leurs intermediares, utiles comme medicaments antidepresseurs
作者:	Taylor, C.R.Jr. (A.H. Robins Co. Inc.)
来源:	BE 0891666; FR 2515183; JP 58065290

合成路线图解说明: The cyclization of 2-aminobenzophenone (I) with 3-amino-2-chloropyridine (II) by means of NaOH in methylene chloride-water gives 6-phenyl-11H-[2,3-b][1,4]benzodiazepine (III), which is then condensed with (3-chloropropyl)dimethylamine by means of NaH in hot DMF, followed by a treatment with fumaric acid in isopropanol.

参考文献No.	63702
标题:	AHR-9377
作者:	Serradell, M.N.; Casta馿r, J.; Souto, M.E.
来源:	Drugs Fut 1984,9(3),163

合成路线图解说明: The cyclization of 2-aminobenzophenone (I) with 3-amino-2-chloropyridine (II) by means of NaOH in methylene chloride-water gives 6-phenyl-11H-[2,3-b][1,4]benzodiazepine (III), which is then condensed with (3-chloropropyl)dimethylamine by means of NaH in hot DMF, followed by a treatment with fumaric acid in isopropanol.