【药物名称】AdThd
化学结构式(Chemical Structure):
参考文献No.63569
标题:AdThd
作者:Blancafort, P.; Hopkins, S.J.; Casta馿r, J.; Serradell, M.N.
来源:Drugs Fut 1983,8(3),179
合成路线图解说明:

The reaction of thymidine (I) with tosyl chloride in pyridine gives 5'-O-tosylthymidine (II), which by reaction with lithium azide is converted into 5'-azido-5'-deoxythymidine (III). Finally, this compound is reduced with H2 over PtO2 in ethanol.

参考文献No.607183
标题:Synthesis and biological activity of several amino analogues of thymidine
作者:Lin, T.S.; Prusoff, W.H.
来源:J Med Chem 1978,21(1),109-112
合成路线图解说明:

The reaction of thymidine (I) with tosyl chloride in pyridine gives 5'-O-tosylthymidine (II), which by reaction with lithium azide is converted into 5'-azido-5'-deoxythymidine (III). Finally, this compound is reduced with H2 over PtO2 in ethanol.

参考文献No.800338
标题:Nucleosides. I. 5'-Amino-5'-deoxyuridine and 5'-amino-5'-deoxythymidine
作者:Urbanski, J.A.; Chua, J.; Tomson, A.J.; Horwitz, J.P.
来源:J Org Chem 1962,273045-48
合成路线图解说明:

The reaction of thymidine (I) with tosyl chloride in pyridine gives 5'-O-tosylthymidine (II), which by reaction with lithium azide is converted into 5'-azido-5'-deoxythymidine (III). Finally, this compound is reduced with H2 over PtO2 in ethanol.

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