Azelastine hydrochloride, W-2979M, E-0659, A-5610, Optivar, Azep, Corifina, Optilast, Afluon, Radethazin, Astelin, Allergodil, Rhinolast, Azeptin-药物合成数据库

【药物名称】Azelastine hydrochloride, W-2979M, E-0659, A-5610, Optivar, Azep, Corifina, Optilast, Afluon, Radethazin, Astelin, Allergodil, Rhinolast, Azeptin

化学结构式(Chemical Structure):

参考文献No.	49261
标题:	Azelastine
作者:	Hillier, K.; Blancafort, P.; Casta馿r, J.; Serradell, M.N.
来源:	Drugs Fut 1980,5(3),123

合成路线图解说明: The cyclization of alpha-(p-chlorophenyl)acetophenone-o-carboxylic acid (I) with hydrazine sulfate by means of NaOH in water gives 4-(p-chlorobenzyl)-1-(2H)-phthalazinone (II), which is then condensed with 2-(2-chloroethyl)-N-methylpyrrolidine (III) by means of NaOH in hot water.

参考文献No.	700891
标题:	Basically substituted benzyl phthalazone derivatives acid salts thereof and process for the production thereof
作者:	Vogelsong, D.; et al.
来源:	US 3813384

合成路线图解说明: The cyclization of alpha-(p-chlorophenyl)acetophenone-o-carboxylic acid (I) with hydrazine sulfate by means of NaOH in water gives 4-(p-chlorobenzyl)-1-(2H)-phthalazinone (II), which is then condensed with 2-(2-chloroethyl)-N-methylpyrrolidine (III) by means of NaOH in hot water.