Anipamil-药物合成数据库

【药物名称】Anipamil

化学结构式(Chemical Structure):

参考文献No.	110
标题:	omega-Cyano-1, omega-diphenyl-azaalkiane derivatives, their preparation and drugs containing them
作者:	Ehrmann, O.; et al. (BASF AG)
来源:	DE 3144150

合成路线图解说明: By condensation of 2-(3-methoxyphenyl)tetradecanenitrile (I) [prepared by alkylation of 3-methoxyphenylacetonitrile (III) with 1-bromoundecane (IV) with 1-chloro-4-methyl-6-(3-methoxyphenyl)-4-azahexane (II) (prepared by alkylation of N-methyl-[2-(3-methoxyphenyl)ethylamine (VI) with 1-bromo-3-chloropropane (V)) by means of sodium amide in refluxing toluene.

参考文献No.	63608
标题:	Anipamil
作者:	Casta馿r, J.; Prous, J.
来源:	Drugs Fut 1986,11(3),171

合成路线图解说明: By condensation of 2-(3-methoxyphenyl)tetradecanenitrile (I) [prepared by alkylation of 3-methoxyphenylacetonitrile (III) with 1-bromoundecane (IV) with 1-chloro-4-methyl-6-(3-methoxyphenyl)-4-azahexane (II) (prepared by alkylation of N-methyl-[2-(3-methoxyphenyl)ethylamine (VI) with 1-bromo-3-chloropropane (V)) by means of sodium amide in refluxing toluene.