KF-4317-药物合成数据库

【药物名称】KF-4317

化学结构式(Chemical Structure):

参考文献No.	46474
标题:	Amino-alcohol derivatives
作者:	Takizawa, H.; Oiji, Y.; Kubo, K. (Kyowa Hakko Kogyo Co., Ltd.)
来源:	DE 3010752; US 4381398

合成路线图解说明: The addition of N-benzyl-3-phenyl-1-methylpropylamine (I) to ethyl 4-(2,3-oxidopropoxy)phenylacetate (II) in refluxing ethanol, followed by debenzylation with H2 over Pd/C gives 1-[4-(ethoxycarbonylmethyl)phenoxyl-3-(1-methyl-3-phenylpropylamino)-2-propanol (III), which is then treated with NH3 in ethanol.

参考文献No.	63575
标题:	KF-4317
作者:	Casta馿r, J.; Serradell, M.N.
来源:	Drugs Fut 1984,9(3),189

合成路线图解说明: The addition of N-benzyl-3-phenyl-1-methylpropylamine (I) to ethyl 4-(2,3-oxidopropoxy)phenylacetate (II) in refluxing ethanol, followed by debenzylation with H2 over Pd/C gives 1-[4-(ethoxycarbonylmethyl)phenoxyl-3-(1-methyl-3-phenylpropylamino)-2-propanol (III), which is then treated with NH3 in ethanol.