Lidamidine hydrochloride, WHR-1142A, Lidaral-药物合成数据库

【药物名称】Lidamidine hydrochloride, WHR-1142A, Lidaral

化学结构式(Chemical Structure):

参考文献No.	63622
标题:	Lidamidine hydrochloride
作者:	Roberts, P.J.; Casta馿r, J.
来源:	Drugs Fut 1979,4(3),206

合成路线图解说明: The reaction of 2,6-dimethylaniline (I) with phosgene (II) in refluxing benzene gives 2,6-dimethylphenyl isocyanate (III), which is then condensed with methylguanidine carbonate (A) by means of K2CO3 in THF and treated with HCl to obtain the corresponding hydrochloride.

参考文献No.	700944
标题:	Nouvelles amidinour閑s, leur pr閜aration et leur emploi
作者:
来源:	BE 0844832

合成路线图解说明: The reaction of 2,6-dimethylaniline (I) with phosgene (II) in refluxing benzene gives 2,6-dimethylphenyl isocyanate (III), which is then condensed with methylguanidine carbonate (A) by means of K2CO3 in THF and treated with HCl to obtain the corresponding hydrochloride.