Torsemide, Torasemide, BM-02015, JDL-464, AC-4464, GJ-1090, Sutril, Torocard, Torasemide N, Unat, Dilutol, Luprac, Torem, Torrem, Toradiur, Demadex, Sutril-药物合成数据库

【药物名称】Torsemide, Torasemide, BM-02015, JDL-464, AC-4464, GJ-1090, Sutril, Torocard, Torasemide N, Unat, Dilutol, Luprac, Torem, Torrem, Toradiur, Demadex, Sutril

化学结构式(Chemical Structure):

参考文献No.	46493
标题:	3-Loweralkylcarbamylsulfonamido-4-phenylaminopyridine-N-oxides, derivatives thereof and pharmaceutical compositions containing same
作者:	Delarge, J.E.; Lapiere, C.L.; Georges, A.M. (A. Christiaens SA)
来源:	BE 0827844; CH 609045; CH 610890; DD 121936; DD 126887; DE 2516025; FR 2267775; GB 1477664; JP 50142571; NL 7504521; US 4018929; US 4055650; ZA 7502243

合成路线图解说明: 1) By condensation of 3-sulfonamido-4-(3-methylanilino)pyridine (I) with isopropylisocyanate (II) by means of triethylamine at 95 C.

合成路线图解说明: 2) By condensation of m-toluidine (III) with 1-isopropyl-3-(4-chloro-3-pyridylsulfonyl)urea (IV) by means of Cu at 95 C.

参考文献No.	63620
标题:	Torasemide
作者:	Casta馿r, J.; Blancafort, P.; Thorpe, P.; Serradell, M.N.
来源:	Drugs Fut 1983,8(3),223

合成路线图解说明: 1) By condensation of 3-sulfonamido-4-(3-methylanilino)pyridine (I) with isopropylisocyanate (II) by means of triethylamine at 95 C.

合成路线图解说明: 2) By condensation of m-toluidine (III) with 1-isopropyl-3-(4-chloro-3-pyridylsulfonyl)urea (IV) by means of Cu at 95 C.