【药物名称】Mifobate, SR-202
化学结构式(Chemical Structure):
参考文献No.65138
标题:SR-202
作者:Nguyen, M.L.; Bentzen, C.L.
来源:Drugs Fut 1982,7(4),271
合成路线图解说明:

The reaction of chlorobenzoyl chloride (I) with trimethyl phosphite gives dimethyl p-chlorobenzoylphosphonate (II). Addition of dimethyl phosphite to (II) in the presence of 80% molar amount of an organic base (e.g., di-n-butylamine) in diethyl ether or toluene at 0 C produces the final compound.

参考文献No.701298
标题:
作者:Bentzen, C.L.; Nguyen, M.L.; Niesor, E.
来源:US 4309364
合成路线图解说明:

The reaction of chlorobenzoyl chloride (I) with trimethyl phosphite gives dimethyl p-chlorobenzoylphosphonate (II). Addition of dimethyl phosphite to (II) in the presence of 80% molar amount of an organic base (e.g., di-n-butylamine) in diethyl ether or toluene at 0 C produces the final compound.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us