Pelubiprofen, CS-670, RS-2131-药物合成数据库

【药物名称】Pelubiprofen, CS-670, RS-2131

化学结构式(Chemical Structure):

参考文献No.	46485
标题:	Cycloalkylidenemethylphenylacetic acid derivatives and process for the preparation thereof
作者:	Terada, A.; Tanaka, S.; Misaka, E. (Sankyo Co., Ltd.)
来源:	BE 0869721; DE 2835701; FR 2400500; GB 2002762; JP 7932460; JP 8257019; US 4254274; US 4365076

合成路线图解说明: The condensation of pyrrolidinocyclohexene (I) with ethyl 2-(4-formylphenyl)propionate (II) in refluxing benzene gives ethyl 2-[4-(2-oxocyclohexylidenemethyl)phenyl)propionate (III), which is hydrolyzed with HBr in refluxing dioxane water.

参考文献No.	65161
标题:	RS-2131
作者:	Serradell, M.N.; Casta馿r, J.
来源:	Drugs Fut 1984,9(4),275

合成路线图解说明: The condensation of pyrrolidinocyclohexene (I) with ethyl 2-(4-formylphenyl)propionate (II) in refluxing benzene gives ethyl 2-[4-(2-oxocyclohexylidenemethyl)phenyl)propionate (III), which is hydrolyzed with HBr in refluxing dioxane water.