Tiobutarit, Bucillamine, DE-019, SA-96, Rimatil-药物合成数据库

【药物名称】Tiobutarit, Bucillamine, DE-019, SA-96, Rimatil

化学结构式(Chemical Structure):

参考文献No.	46968
标题:	Cysteine derivatives
作者:	Fujita, T.; et al. (Santen Pharmaceutical Co., Ltd.)
来源:	DE 2709820; FR 2344533; GB 1530071; JP 53005112; US 4137420; US 4305958

合成路线图解说明: The condensation of 2-benzylmercaptoisobutyryl chloride (I) with S-benzyl-L-cysteine (II) by means of NaOH in water gives N-(2-benzylmercaptoisobutyryl)-S-benzyl-L-cysteine (III), which is treated with Na in liquid ammonia.

参考文献No.	49359
标题:	SA-96
作者:	Casta馿r, J.; Arrigoni-Martelli, E.; Blancafort, P.; Serradell, M.N.
来源:	Drugs Fut 1981,6(5),292

合成路线图解说明: The condensation of 2-benzylmercaptoisobutyryl chloride (I) with S-benzyl-L-cysteine (II) by means of NaOH in water gives N-(2-benzylmercaptoisobutyryl)-S-benzyl-L-cysteine (III), which is treated with Na in liquid ammonia.