【药物名称】Ametantrone acetate, NSC-287513(diacetate), NSC-196473(free base), CI-881
化学结构式(Chemical Structure):
参考文献No.65804
标题:Ametantrone acetate
作者:Blancafort, P.; Serradell, M.N.; Casta馿r, J.; Hillier, K.
来源:Drugs Fut 1982,7(5),303
合成路线图解说明:

By condensation of 2,3-dihydro-1,4-dihydroxyanthraquinone (I) with N-(aminoethyl)ethanolamine (II) in refluxing ethanol, followed by oxidation with air and treatment with acetic acid.

参考文献No.607186
标题:Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones
作者:Murdock, K.C.; Child, R.G.; Fabio, P.F.; Angier, R.B.; Wallace, R.E.; Durr, F.E.; Citarella, R.V.
来源:J Med Chem 1979,22(9),1024
合成路线图解说明:

By condensation of 2,3-dihydro-1,4-dihydroxyanthraquinone (I) with N-(aminoethyl)ethanolamine (II) in refluxing ethanol, followed by oxidation with air and treatment with acetic acid.

合成路线图解说明:

By condensation of 1,4,5,8-tetrahydroxyanthraquinone (I) with ethylenediamine (II) in hot tetramethylethylenediamine.

参考文献No.701307
标题:
作者:Hoare, R.C.
来源:US 4051155
合成路线图解说明:

By condensation of 2,3-dihydro-1,4-dihydroxyanthraquinone (I) with N-(aminoethyl)ethanolamine (II) in refluxing ethanol, followed by oxidation with air and treatment with acetic acid.

参考文献No.701308
标题:
作者:Hoare, R.C.
来源:FR 2399244
合成路线图解说明:

By condensation of 2,3-dihydro-1,4-dihydroxyanthraquinone (I) with N-(aminoethyl)ethanolamine (II) in refluxing ethanol, followed by oxidation with air and treatment with acetic acid.

参考文献No.701309
标题:
作者:Hoare, R.C.
来源:DE 2734907
合成路线图解说明:

By condensation of 2,3-dihydro-1,4-dihydroxyanthraquinone (I) with N-(aminoethyl)ethanolamine (II) in refluxing ethanol, followed by oxidation with air and treatment with acetic acid.

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