Itazogrel, Itazigrel, U-53059, TFT-药物合成数据库

【药物名称】Itazogrel, Itazigrel, U-53059, TFT

化学结构式(Chemical Structure):

参考文献No.	65726
标题:	TFT
作者:	Serradell, M.N.; Casta馿r, J.; Blancafort, P.
来源:	Drugs Fut 1982,7(5),323

合成路线图解说明: The amonolysis of trifluoroacetonitrile (I) in refluxing liquid ammonia gives trifluoroacetamidine (II), which by reaction with SH2 in ether is converted into trifluorothioacetamide (III). Finally, this compound is cyclized with p-methoxy-alpha-bromo-alpha-(p-methoxyphenyl)acetophenone (IV) in refluxing acetonitrile.

参考文献No.	701304
标题:
作者:	Rynbrandt, R.H.; Nishizawa, E.E.
来源:	US 4168315

合成路线图解说明: The amonolysis of trifluoroacetonitrile (I) in refluxing liquid ammonia gives trifluoroacetamidine (II), which by reaction with SH2 in ether is converted into trifluorothioacetamide (III). Finally, this compound is cyclized with p-methoxy-alpha-bromo-alpha-(p-methoxyphenyl)acetophenone (IV) in refluxing acetonitrile.