Atrimustine, Busramustine, Bestrabucil, KM-2210, Kregan-药物合成数据库

【药物名称】Atrimustine, Busramustine, Bestrabucil, KM-2210, Kregan

化学结构式(Chemical Structure):

参考文献No.	65800
标题:	KM-2210
作者:	Casta馿r, J.; Serradell, M.N.
来源:	Drugs Fut 1984,9(5),334

合成路线图解说明: The benzoylation of 1,3,5(10)-estratrien-3,17beta-diol (I) with benzoyl chloride (II) by means of NaOH in THF-water gives 3-benzoyloxy-1,3,5(10)-estratrien-17beta-ol (III), which is acylated with bromoacetyl bromide (IV) by means of pyridine in THF-CCl4 yielding 3-benzoyloxy-17beta-bromoacetoxy 1,3,5(10)-estratriene (V). Finally, this compound is condensed with silver 4-[4-[bis(2-chloroethyl)amino]phenyl]butyrate (VI) in DMSO.

参考文献No.	701153
标题:	Novel estradiol compound, its preparation and anti-tumor agent containing the same
作者:	Asano, K.; Tamura, H.; Tanaka, H.; Enomoto, S.
来源:	BE 0878186; JP 55027121

合成路线图解说明: The benzoylation of 1,3,5(10)-estratrien-3,17beta-diol (I) with benzoyl chloride (II) by means of NaOH in THF-water gives 3-benzoyloxy-1,3,5(10)-estratrien-17beta-ol (III), which is acylated with bromoacetyl bromide (IV) by means of pyridine in THF-CCl4 yielding 3-benzoyloxy-17beta-bromoacetoxy 1,3,5(10)-estratriene (V). Finally, this compound is condensed with silver 4-[4-[bis(2-chloroethyl)amino]phenyl]butyrate (VI) in DMSO.