Linogliride, McN-3935-药物合成数据库

【药物名称】Linogliride, McN-3935

化学结构式(Chemical Structure):

参考文献No.	45888
标题:	Nitrogen heterocyclic carboximidamide compounds
作者:	Rasmussen, C.R. (Ortho-McNeil Pharmaceutical, Inc.)
来源:	US 4211867

合成路线图解说明: The reaction of phenyl isothiocyanate (I) with 2-imino-1-methyl pyrrolidine (II) in benzene gives N-(1-methyl-2-pyrrolidinylidene)-N'-phenylthiourea (III), which is treated with iodomethane in refluxing acetone to afford methyl N-1-methyl-2-pyrrolidinylidene)-N'-phenylcarbamidothioate (IV). Finally, this compound is treated with morpholine in refluxing isopropanol.

参考文献No.	65227
标题:	Linogliride
作者:	Casta馿r, J.; Serradell, M.N.
来源:	Drugs Fut 1986,11(4),265

合成路线图解说明: The reaction of phenyl isothiocyanate (I) with 2-imino-1-methyl pyrrolidine (II) in benzene gives N-(1-methyl-2-pyrrolidinylidene)-N'-phenylthiourea (III), which is treated with iodomethane in refluxing acetone to afford methyl N-1-methyl-2-pyrrolidinylidene)-N'-phenylcarbamidothioate (IV). Finally, this compound is treated with morpholine in refluxing isopropanol.