【药物名称】Nisoldipine, Bay-k-5552, Sular, Baymycard, Syscor
化学结构式(Chemical Structure):
参考文献No.46976
标题:2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
作者:Wehinger, E.; et al. (Bayer AG)
来源:US 4154839
合成路线图解说明:

By cyclization of isobutyl 2-(2-nitrobenzylidene)acetoacetate (I) and methyl 3-aminocrotonate (II) in refluxing ethanol.

参考文献No.49366
标题:Nisoldipine
作者:McGillion, F.B.; Casta馿r, J.; Blancafort, P.; Serradell, M.N.
来源:Drugs Fut 1981,6(6),360
合成路线图解说明:

By cyclization of isobutyl 2-(2-nitrobenzylidene)acetoacetate (I) and methyl 3-aminocrotonate (II) in refluxing ethanol.

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