FPL-52694-药物合成数据库

【药物名称】FPL-52694

化学结构式(Chemical Structure):

参考文献No.	67200
标题:	FPL-52,694
作者:	Sneddon, J.M.; Serradell, M.N.; Casta馿r, J.; Blancafort, P.
来源:	Drugs Fut 1982,7(6),388

合成路线图解说明: The hydrogenation of 2-hydroxy-3-allyl-6-(2-hydroxypropoxy)acetophenone (I) with H2 over Pd/C in ethanol gives 2-hydroxy-3-propyl-6-(2-hydroxypropoxy)acetophenone (II), which is then cyclized with diethyl oxalate (III) by means of sodium ethoxide in refluxing ethanol. The sodium salt is prepared by treatment of the acid with NaHCO3 in water.

参考文献No.	701319
标题:
作者:	Cairns, H.; Hazard, R.; King, J.; Lee, T.B.
来源:	DE 2530289

合成路线图解说明: The hydrogenation of 2-hydroxy-3-allyl-6-(2-hydroxypropoxy)acetophenone (I) with H2 over Pd/C in ethanol gives 2-hydroxy-3-propyl-6-(2-hydroxypropoxy)acetophenone (II), which is then cyclized with diethyl oxalate (III) by means of sodium ethoxide in refluxing ethanol. The sodium salt is prepared by treatment of the acid with NaHCO3 in water.