【药物名称】Vibunazole, Bay-n-7133
化学结构式(Chemical Structure):
参考文献No.67103
标题:BAY-N-7133
作者:Fromtling, R.A.; Serradell, M.N.; Casta馿r, J.
来源:Drugs Fut 1984,9(6),404
合成路线图解说明:

The reaction of 1-(4-chlorophenoxy)-3,3-dimethyl-2-butanone (I) with dimethyl sulfide, dimethyl sulfate and sodium methoxide in acetonitrile gives 2,4-chlorophenoxymethyl)-2-(tertbutyl)oxirane (II), which is then condensed with 1,2,4-triazole (III) in refluxing ethanol.

参考文献No.701169
标题:Oxirane compounds
作者:Holmwood, G.; Buechel, K.H.; Luerssen, K.; Frohberger, P.E.; Brandes, W.
来源:EP 0040345; EP 0072580; EP 0087148; ES 8203859; JP 2167270; JP 2167273; US 4532341; US 4626595; US 4723984; US 4789672; US 4871390; US 4897107; US 4904298; US 4911746
合成路线图解说明:

The reaction of 1-(4-chlorophenoxy)-3,3-dimethyl-2-butanone (I) with dimethyl sulfide, dimethyl sulfate and sodium methoxide in acetonitrile gives 2,4-chlorophenoxymethyl)-2-(tertbutyl)oxirane (II), which is then condensed with 1,2,4-triazole (III) in refluxing ethanol.

参考文献No.701170
标题:Antimicrobial azoles
作者:Holmwood, G.; Buechel, K.H.; Plempel, M.; Haller, T.
来源:DE 3018865; EP 0043419; JP 57009715; US 4652579
合成路线图解说明:

The reaction of 1-(4-chlorophenoxy)-3,3-dimethyl-2-butanone (I) with dimethyl sulfide, dimethyl sulfate and sodium methoxide in acetonitrile gives 2,4-chlorophenoxymethyl)-2-(tertbutyl)oxirane (II), which is then condensed with 1,2,4-triazole (III) in refluxing ethanol.

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