Alnovin, Fendosal, P 71-0129, HP-129-药物合成数据库

【药物名称】Alnovin, Fendosal, P 71-0129, HP-129

化学结构式(Chemical Structure):

参考文献No.	68110
标题:	Fendosal
作者:	Casta馿r, J.; Arrigoni-Martelli, E.
来源:	Drugs Fut 1976,1(7),320

合成路线图解说明: The reaction of beta-tetralone (I) with pyrrolidine (A) yields enamine (II), which is condensed with phenacyl bromide (B) in DMF to give the 1-phenacyl-2-tetralone (III). Finally, this diketone is cyclized with 5-aminosalycilic acid (C) in refluxing acetic acid.

参考文献No.	607175
标题:	Carboxyarylindoles as non steroidal anti-inflammatory agents
作者:	Anderson, V.B.; Agnew, M.N.; Allen, R.C.; Wilker, J.C.; Lassman, H.B.; Novick, W.J. Jr.
来源:	J Med Chem 1976,1(7),320

合成路线图解说明: The reaction of beta-tetralone (I) with pyrrolidine (A) yields enamine (II), which is condensed with phenacyl bromide (B) in DMF to give the 1-phenacyl-2-tetralone (III). Finally, this diketone is cyclized with 5-aminosalycilic acid (C) in refluxing acetic acid.