This compound can be obtained in two different ways: 1) The acylation of 1-benzylamino-3-[2-(2-thenyl)phenoxy]-2-propanol (I) with chloroacetyl chloride (II) by means of triethylamine in CHCl3 gives N-[2-hydroxy-3-[2-(2-thenyl)phenoxy)propyl]-N-benzylchloroacetamide (III), which is cyclized by treatment with sodium methoxide in refluxing methanol yielding N-benzyl-2-[2-(2-thenyl)phenoxymethyl]morpholin-5-one (IV). The reduction of (IV) with LiAlH4 in refluxing ether affords N-benzyl-2-[2-(2-thenyl)phenoxymethyl]morpholine (V), which is debenzylated by treatment with ethyl chlorotormate (A) in refluxing toluene giving N-ethoxycarbonyl-2-[2-(2-thenyl)phenoxymethyl]morpholine (VI). Finally, this compound is decarboxylated by treatment with barium hydroxide in refluxing water and treated with maleic acid (B). 2) By cyclization of 1-[2-(2-thenyl)phenoxy]-2,3-epoxypropane (VII) with 2-aminoethyl hydrogen sulfate (VIII) by means of NaOH in refluxing water. Finally, the resulting compound is treated with maleic acid (B).

This compound can be obtained in two different ways: 1) The acylation of 1-benzylamino-3-[2-(2-thenyl)phenoxy]-2-propanol (I) with chloroacetyl chloride (II) by means of triethylamine in CHCl3 gives N-[2-hydroxy-3-[2-(2-thenyl)phenoxy)propyl]-N-benzylchloroacetamide (III), which is cyclized by treatment with sodium methoxide in refluxing methanol yielding N-benzyl-2-[2-(2-thenyl)phenoxymethyl]morpholin-5-one (IV). The reduction of (IV) with LiAlH4 in refluxing ether affords N-benzyl-2-[2-(2-thenyl)phenoxymethyl]morpholine (V), which is debenzylated by treatment with ethyl chlorotormate (A) in refluxing toluene giving N-ethoxycarbonyl-2-[2-(2-thenyl)phenoxymethyl]morpholine (VI). Finally, this compound is decarboxylated by treatment with barium hydroxide in refluxing water and treated with maleic acid (B). 2) By cyclization of 1-[2-(2-thenyl)phenoxy]-2,3-epoxypropane (VII) with 2-aminoethyl hydrogen sulfate (VIII) by means of NaOH in refluxing water. Finally, the resulting compound is treated with maleic acid (B).

This compound can be obtained in two different ways: 1) The acylation of 1-benzylamino-3-[2-(2-thenyl)phenoxy]-2-propanol (I) with chloroacetyl chloride (II) by means of triethylamine in CHCl3 gives N-[2-hydroxy-3-[2-(2-thenyl)phenoxy)propyl]-N-benzylchloroacetamide (III), which is cyclized by treatment with sodium methoxide in refluxing methanol yielding N-benzyl-2-[2-(2-thenyl)phenoxymethyl]morpholin-5-one (IV). The reduction of (IV) with LiAlH4 in refluxing ether affords N-benzyl-2-[2-(2-thenyl)phenoxymethyl]morpholine (V), which is debenzylated by treatment with ethyl chlorotormate (A) in refluxing toluene giving N-ethoxycarbonyl-2-[2-(2-thenyl)phenoxymethyl]morpholine (VI). Finally, this compound is decarboxylated by treatment with barium hydroxide in refluxing water and treated with maleic acid (B). 2) By cyclization of 1-[2-(2-thenyl)phenoxy]-2,3-epoxypropane (VII) with 2-aminoethyl hydrogen sulfate (VIII) by means of NaOH in refluxing water. Finally, the resulting compound is treated with maleic acid (B).