Murocainide, MD-750819(HCl)-药物合成数据库

【药物名称】Murocainide, MD-750819(HCl)

化学结构式(Chemical Structure):

参考文献No.	47443
标题:	Novel aminoalkoxybenzofurans, their process of preparation and their therapeutic use
作者:	Bourgery, G.; Lacour, A.; Pourrias, B.; Bregeon, G.C. (Laboratoires Delalande)
来源:	FR 2358143

合成路线图解说明: The condensation of 5-acetamido-4,7-dimethoxy-6-hydroxybenzofuran (I) with N-(2-chloroethyl)piperidine (II) by means of K2CO3 in refluxing acetone gives 5-acetamido-4,7-dimethoxy-6-[2-(N-piperidino)ethoxy]benzofuran (III), which is hydrolyzed with refluxing 2N HCl yielding 5-amino-4,7-dimethoxy-6-[2-(N-piperidino)ethoxy]benzofuran (IV). Finally, this compound is treated with methyl isocyanate (V) in hot toluene.

参考文献No.	70115
标题:	Murocainide
作者:	Serradell, M.N.; Casta馿r, J.; Blancafort, P.; Thorpe, P.J.
来源:	Drugs Fut 1983,8(8),687

合成路线图解说明: The condensation of 5-acetamido-4,7-dimethoxy-6-hydroxybenzofuran (I) with N-(2-chloroethyl)piperidine (II) by means of K2CO3 in refluxing acetone gives 5-acetamido-4,7-dimethoxy-6-[2-(N-piperidino)ethoxy]benzofuran (III), which is hydrolyzed with refluxing 2N HCl yielding 5-amino-4,7-dimethoxy-6-[2-(N-piperidino)ethoxy]benzofuran (IV). Finally, this compound is treated with methyl isocyanate (V) in hot toluene.