Alacepril, DU-1219, Cetapril-药物合成数据库

【药物名称】Alacepril, DU-1219, Cetapril

化学结构式(Chemical Structure):

参考文献No.	13172
标题:	1-(3-Mercapto-2-methylpropanoyl)prolylamino acid derivs.
作者:	Sawayama, T.; Kinugasa, H.; Nishimura, A.; Takeyama, K.; Hosoki, K. (Dainippon Pharmaceutical Co., Ltd.)
来源:	JP 1980009058; US 4248883

合成路线图解说明: The condensation of 1-(D-3-acetylthio-2-methylpropanoyl)-L-proline (I) with L-phenylalanine tert-butyl ester (II) by means of N-methylmorpholine and phenyl chloroformate in THF gives 1-(D-3-acetyl-thio-2-methylpropanoyl)-L-prolyl-L-phenylalanine tert-butyl ester (III), which is hydrolyzed with trifluoroacetic acid in anisole.

参考文献No.	64383
标题:	Alacepril
作者:	Casta馿r, J.; Mannhold, R.
来源:	Drugs Fut 1986,11(5),357

合成路线图解说明: The condensation of 1-(D-3-acetylthio-2-methylpropanoyl)-L-proline (I) with L-phenylalanine tert-butyl ester (II) by means of N-methylmorpholine and phenyl chloroformate in THF gives 1-(D-3-acetyl-thio-2-methylpropanoyl)-L-prolyl-L-phenylalanine tert-butyl ester (III), which is hydrolyzed with trifluoroacetic acid in anisole.