Tazasubrate, EMD-34853-药物合成数据库

【药物名称】Tazasubrate, EMD-34853

化学结构式(Chemical Structure):

参考文献No.	71709
标题:	Tazasubrate
作者:	Serradell, M.N.; Casta馿r, J.
来源:	Drugs Fut 1984,9(9),667

合成路线图解说明: This compound can be obtained by two different ways: 1) The condensation of 2-mercapto-6-ethoxybenzothiazole (I) with 2-bromo-2-phenylpropionate (II) by means of sodium ethoxide in refluxing ethanol gives 2-phenyl-2-[(6-ethoxy-2-benzothiazoyl)thio]propionate (III), which is then hydrolyzed with KOH in ethanol. 2) By condensation of 2-chloro-6-ethoxybenzothiazole (IV) with 2-mercapto-2-phenylpropionic acid (V) by means of NaOH in refluxing butanol.

参考文献No.	701174
标题:	Benzothiazole derivatives and pharmaceutical formulations containing them
作者:	Doll, T.; Scacht, E.; Radunz, H.E.; Schulze, E.
来源:	DE 2950095; EP 0030632; ES 8203867; JP 56092881; US 4294839

合成路线图解说明: This compound can be obtained by two different ways: 1) The condensation of 2-mercapto-6-ethoxybenzothiazole (I) with 2-bromo-2-phenylpropionate (II) by means of sodium ethoxide in refluxing ethanol gives 2-phenyl-2-[(6-ethoxy-2-benzothiazoyl)thio]propionate (III), which is then hydrolyzed with KOH in ethanol. 2) By condensation of 2-chloro-6-ethoxybenzothiazole (IV) with 2-mercapto-2-phenylpropionic acid (V) by means of NaOH in refluxing butanol.