Deloxolone sodium, ISF-2715-药物合成数据库

【药物名称】Deloxolone sodium, ISF-2715

化学结构式(Chemical Structure):

参考文献No.	46544
标题:	3beta-Hydroxy-18beta-olean-9-en-30-oic acids
作者:	Pifferi, G.; Umani Ronchi, A.; Farina, C.; Gamba, A. (ISF SpA)
来源:	DE 2811253; FR 2383909; GB 1575494; JP 78116363; US 4173648

合成路线图解说明: The oxidation of 3-beta-acetoxyolean-12-en-30-oic acid methyl ester (I) with H2O2 in hot acetic acid gives 3beta-acetoxy-12-oxoolean-30-oic acid methyl ester (II), which is treated with Br2 in 40% HBr acetic acid yielding 3beta-acetoxy-12-oxoolean 9-en-30-oic acid methyl ester (III). The reduction of (III) with hydrazine and sodium ethoxide in ethanol affords 3beta-hydroxyolean-9(11)-en-30-oic acid (IV), which is finally esterified with succinic anhydride (V) in hot pyridine.

参考文献No.	70119
标题:	Deloxolone sodium
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1986,11(8),643

合成路线图解说明: The oxidation of 3-beta-acetoxyolean-12-en-30-oic acid methyl ester (I) with H2O2 in hot acetic acid gives 3beta-acetoxy-12-oxoolean-30-oic acid methyl ester (II), which is treated with Br2 in 40% HBr acetic acid yielding 3beta-acetoxy-12-oxoolean 9-en-30-oic acid methyl ester (III). The reduction of (III) with hydrazine and sodium ethoxide in ethanol affords 3beta-hydroxyolean-9(11)-en-30-oic acid (IV), which is finally esterified with succinic anhydride (V) in hot pyridine.