Ridazolol-药物合成数据库

【药物名称】Ridazolol

化学结构式(Chemical Structure):

参考文献No.	42027
标题:	N-phenoxypropanol-N'-pyridazinyl ethylendiamines as beta -receptor blockers
作者:	Raabe, T.; Bohn, H.; Martorana, P.A.; Nitz, R.-E. (Cassella AG)
来源:	DD 202013; DE 3048487; EP 54946; JP 57128677; US 4532239

合成路线图解说明: The condensation of 2-glycidyloxy-1-chlorobenzene (I) with ethylenediamine (II) in refluxing ethanol gives N-[3-(2-chlorophenoxy)-2-hydroxy propyl]ethylenediamine (III), which is then condensed with 4,5-dichloropyridazinone (IV) in refluxing ethanol.

参考文献No.	79481
标题:	Ridazolol
作者:	Casta馿r, J.; Prous, J.
来源:	Drugs Fut 1986,11(12),1044

合成路线图解说明: The condensation of 2-glycidyloxy-1-chlorobenzene (I) with ethylenediamine (II) in refluxing ethanol gives N-[3-(2-chlorophenoxy)-2-hydroxy propyl]ethylenediamine (III), which is then condensed with 4,5-dichloropyridazinone (IV) in refluxing ethanol.