Flavodilol maleate, PR-87730L-药物合成数据库

【药物名称】Flavodilol maleate, PR-87730L

化学结构式(Chemical Structure):

参考文献No.	1048
标题:	Antihypertensive agents
作者:	Wu, E.S.-C. (Pennwalt Corp.)
来源:	EP 0064165; US 4501755

合成路线图解说明: The condensation of epichlorohydrin (I) with 7-hydroxyflavone (II) by means of NaOH in ethanol - water gives 7-(2,3-epoxypropoxy)fIavone (III), which is then treated with propylamine (IV) in methanol, and neutralized with maleic acid.

参考文献No.	61906
标题:	Flavodilol maleate
作者:	Casta馿r, J.; Prous, J.
来源:	Drugs Fut 1986,11(10),837

合成路线图解说明: The condensation of epichlorohydrin (I) with 7-hydroxyflavone (II) by means of NaOH in ethanol - water gives 7-(2,3-epoxypropoxy)fIavone (III), which is then treated with propylamine (IV) in methanol, and neutralized with maleic acid.