【药物名称】Roxithromycin, RU-965, RU-28965, Rossitrol, Overall, Assoral, Rulid
化学结构式(Chemical Structure):
参考文献No.41900
标题:Novel erythromycin a derivatives
作者:Gouin, A.S.; Lutz, A.; Gasc, J.-C. (Aventis Pharmaceuticals, Inc.)
来源:EP 0033255; FR 2473525; JP 81100799; US 4349545
合成路线图解说明:

By condensation of erythromycin oxime (II) [obtained from erythromycin (I) and hydroxylamine hydrochloride] with (2 methoxyethoxy)methyl chloride (III) in the presence of NaHCO3 in refluxing acetone.

参考文献No.49444
标题:Roxithromycin
作者:Casta馿r, J.; Prous, J.
来源:Drugs Fut 1986,11(9),767
合成路线图解说明:

By condensation of erythromycin oxime (II) [obtained from erythromycin (I) and hydroxylamine hydrochloride] with (2 methoxyethoxy)methyl chloride (III) in the presence of NaHCO3 in refluxing acetone.

参考文献No.604968
标题:New ether oxime derivatives of erythromycin A: Preparation and antibacterial activities
作者:Gouin D'Ambrieres, S.; Chantot, J.F.; Gasc, J.C.; Lutz, A.
来源:23rd Intersci Conf Antimicrob Agents Chemother (Oct 24-26, Las Vegas) 1983,Abst 447
合成路线图解说明:

By condensation of erythromycin oxime (II) [obtained from erythromycin (I) and hydroxylamine hydrochloride] with (2 methoxyethoxy)methyl chloride (III) in the presence of NaHCO3 in refluxing acetone.

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