Ro-220654-药物合成数据库

【药物名称】Ro-220654

化学结构式(Chemical Structure):

参考文献No.	46023
标题:	Novel thiophene derivatives
作者:	Confalone, P.N.; Pizzolato, G.; Uskokovic, M.R.; Rouge, M. (Hoffmann-La Roche, Inc.)
来源:	DE 2737738; US 4317915

合成路线图解说明: The cyclization of 2-ethyl-3-thia-1,6-hexanedioic acid 1-ethyl-6-methyl ester (I) by means of sodium methoxide in benzene gives methyl 2-ethyl-3-oxotetrahydrothiophene-4-carboxylate (II), which is treated with hydroxylamine in pyridine to afford the corresponding oxime (III). Finally, this compound is treated with dry HCl in ether.

参考文献No.	65696
标题:	RO-220654
作者:	Thorpe, P.J.; Serradell, M.N.; Casta馿r, J.
来源:	Drugs Fut 1985,10(5),407

合成路线图解说明: The cyclization of 2-ethyl-3-thia-1,6-hexanedioic acid 1-ethyl-6-methyl ester (I) by means of sodium methoxide in benzene gives methyl 2-ethyl-3-oxotetrahydrothiophene-4-carboxylate (II), which is treated with hydroxylamine in pyridine to afford the corresponding oxime (III). Finally, this compound is treated with dry HCl in ether.