【药物名称】Zindotrine, MDL-257
化学结构式(Chemical Structure):
参考文献No.41895
标题:Triazolopyridazines used to alleviate bronchial spasms
作者:Lewis, J.; Shea, P.J. (Aventis Pharmaceuticals, Inc.)
来源:US 4136182
合成路线图解说明:

1) The cyclization of 6-chloro-3-hydrazino-4-methylpyridazine (I) with refluxing formic acid gives 6-chloro-8-methyl-1,2,4-triazolo[4,3-b]pyridazine (II), which is then condensed with piperidine (III) at reflux temperature.

合成路线图解说明:

2) By cyclization of 3-hydrazino-4-methyl-6-piperidinopyridazine (I) in refluxing formic acid.

参考文献No.41899
标题:3,6,7,8-Substituted-s-triazolo[4,3-b]-pyridazines, their preparations and compositions comprising them
作者:Peet, N.P.; Sunder, S. (Aventis Pharmaceuticals, Inc.)
来源:EP 0029130; GB 2061275; JP 56079690
合成路线图解说明:

1) The cyclization of 6-chloro-3-hydrazino-4-methylpyridazine (I) with refluxing formic acid gives 6-chloro-8-methyl-1,2,4-triazolo[4,3-b]pyridazine (II), which is then condensed with piperidine (III) at reflux temperature.

合成路线图解说明:

2) By cyclization of 3-hydrazino-4-methyl-6-piperidinopyridazine (I) in refluxing formic acid.

参考文献No.61893
标题:Zindotrine
作者:Casta馿r, J.; Prous, J.
来源:Drugs Fut 1986,11(10),865
合成路线图解说明:

1) The cyclization of 6-chloro-3-hydrazino-4-methylpyridazine (I) with refluxing formic acid gives 6-chloro-8-methyl-1,2,4-triazolo[4,3-b]pyridazine (II), which is then condensed with piperidine (III) at reflux temperature.

合成路线图解说明:

2) By cyclization of 3-hydrazino-4-methyl-6-piperidinopyridazine (I) in refluxing formic acid.

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