Croconazole hydrochloride, Cloconazole hydrochloride, 710674S, Pilzcin-药物合成数据库

【药物名称】Croconazole hydrochloride, Cloconazole hydrochloride, 710674S, Pilzcin

化学结构式(Chemical Structure):

参考文献No.	49460
标题:	Cloconazole Hydrochloride
作者:	Ogata, M.; Tawara, K.
来源:	Drugs Fut 1985,10(6),451

合成路线图解说明: This 1-vinyl derivative (II) is obtained by reaction of N,N'-thionyldiimidazole (A) with o-hydroxyacetophenone (I) in dichloromethane at room temperature. Treatment of (II) with m-chlorobenzyl chloride (B) in the presence of KOH in DMF gives the m-chlorobenzyl ether (III). The hydrochloride can be prepared by treatment of (III) with HCl in AcOEt.

参考文献No.	607675
标题:	1-[1-[2-[(3-Chlorobenzyl)oxy]phenyl]vinyl]-1H-imidazole hydrochloride, a new potent antifungal agent
作者:	Ogata, M.; Matsumoto, H.; Hamada, Y.; Takehara, M.; Tawara, K.
来源:	J Med Chem 1983,26(5),768-770

合成路线图解说明: This 1-vinyl derivative (II) is obtained by reaction of N,N'-thionyldiimidazole (A) with o-hydroxyacetophenone (I) in dichloromethane at room temperature. Treatment of (II) with m-chlorobenzyl chloride (B) in the presence of KOH in DMF gives the m-chlorobenzyl ether (III). The hydrochloride can be prepared by treatment of (III) with HCl in AcOEt.