【药物名称】CI-844
化学结构式(Chemical Structure):
参考文献No.46033
标题:3-Phenoxypyridine monosulfate and a method for its production
作者:Butler, D.E. (Pfizer Inc.)
来源:BE 0861649; DE 2755016; ES 464922; FR 2392009; GB 1559918; JP 53077068; US 4128555
合成路线图解说明:

3-Phenoxypyridine can be prepared by two different ways: 1) By reaction of 3-hydroxypyridine (I) with bromobenzene (II) by means of KOH and copper bronze at 150 C. 2) By reaction of 3-iodopyridine (III) with phenol (IV) by means of KOH and copper bronze at 150 C. The monosulfate salt is prepared by treating 3-phenoxypyridine with H2SO4.

参考文献No.65203
标题:CI-844
作者:Owen, R.T.; Casta馿r, J.; Serradell, M.N.
来源:Drugs Fut 1985,10(4),279
合成路线图解说明:

3-Phenoxypyridine can be prepared by two different ways: 1) By reaction of 3-hydroxypyridine (I) with bromobenzene (II) by means of KOH and copper bronze at 150 C. 2) By reaction of 3-iodopyridine (III) with phenol (IV) by means of KOH and copper bronze at 150 C. The monosulfate salt is prepared by treating 3-phenoxypyridine with H2SO4.

参考文献No.800012
标题:Quaternary deivation of pyridyl ethers. Onium Compound. XVI
作者:Renshaw, R.R.; Conn, R.C.
来源:J Am Chem Soc 1937,59297-301
合成路线图解说明:

3-Phenoxypyridine can be prepared by two different ways: 1) By reaction of 3-hydroxypyridine (I) with bromobenzene (II) by means of KOH and copper bronze at 150 C. 2) By reaction of 3-iodopyridine (III) with phenol (IV) by means of KOH and copper bronze at 150 C. The monosulfate salt is prepared by treating 3-phenoxypyridine with H2SO4.

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