【药物名称】Bemesetron, MDL-72222
化学结构式(Chemical Structure):
参考文献No.46539
标题:Treatment og migraine with substituted tropyl benzoate derivatives
作者:Fozard, J.R.; Gittos, M.W. (Aventis Pharma SA)
来源:EP 0067770; JP 58000978
合成路线图解说明:

By reaction of tropine (I) with 3,5-dichlorobenzoyl chloride (II) at 140 C.

参考文献No.61916
标题:MDL-72222
作者:Pento, J.T.; Casta馿r, J.; Serradell, M.N.
来源:Drugs Fut 1985,10(10),820
合成路线图解说明:

By reaction of tropine (I) with 3,5-dichlorobenzoyl chloride (II) at 140 C.

参考文献No.175452
标题:Synthesis and regional rat brain distribution of [C-11]MDL 72222 - A 5HT3 receptor antagonist
作者:Lasne, M.C.; Debruyne, D.; Moulin, M.; Baron, J.C.; Camsonne, R.; Barre, L.; Bonvento, G.; Gourand, F.
来源:Appl Radiat Isot - Int J Radiat Appl Instrum Part A 1992,43(4),509
合成路线图解说明:

The synthesis of [11C]-labeled MDL-72222 for use in PET studies of the 5-HT3 receptor by methylation of 3,5-dichlorobenzoic acid 8-azabicyclo[3.2.1]oct-3-yl ester (I) with [11C]-labeled methyl iodide in hot acetonitrile has been described.

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