Iproplatin, NSC-256927, CHIP, JM-9-药物合成数据库

【药物名称】Iproplatin, NSC-256927, CHIP, JM-9

化学结构式(Chemical Structure):

参考文献No.	40775
标题:	cis-Dichloro-trans-dihydroxy-bis(isopropylamine)platinum(IV), preparation and intermediate
作者:	Hepburn, D.R.; Hydes, P.C. (Johnson Matthey plc)
来源:	BE 890209; JP 1982077694

合成路线图解说明: Iproplatin is prepared by treating cis-dichlorobis(isopropylamine)platinum (I) with hydrogen peroxide, mixing the product by N,N-dimetylacetamide at 5 C to give iproplatin-dimethylacetamide 1:1 addiction product (II). After elimination of N,N-dimethylacetamide by heating (II) at 50 C / 0.1 torr iproplatin is obtained.

参考文献No.	66402
标题:	Iroplatin
作者:	Chang, P.
来源:	Drugs Fut 1985,10(7),561

合成路线图解说明: Iproplatin is prepared by treating cis-dichlorobis(isopropylamine)platinum (I) with hydrogen peroxide, mixing the product by N,N-dimetylacetamide at 5 C to give iproplatin-dimethylacetamide 1:1 addiction product (II). After elimination of N,N-dimethylacetamide by heating (II) at 50 C / 0.1 torr iproplatin is obtained.