Pelanserin hydrochloride, TR-2515-药物合成数据库

【药物名称】Pelanserin hydrochloride, TR-2515

化学结构式(Chemical Structure):

参考文献No.	75281
标题:	TR-2515
作者:	Schut, R.N.; Hong, E.
来源:	Drugs Fut 1985,10(11),929

合成路线图解说明: The reaction of isatoic anhydride (I) with 1-(3-aminopropyl)-4-phenylpiperazine (II) in DMF at 40-60 C gives the o-aminobenzamide derivative (III), which is then cyclized by the action of phosgene in refluxing chlorobenzene.

参考文献No.	608293
标题:	New sedative and hypotensive 3-substituted 2,4(1H,3H)-quinazolinediones
作者:	Hayao, S.; Havera, H.J.; Strycker, W.G.; Leipzig, T.J.; Kulp, R.A.; Hartzler, H.E.
来源:	J Med Chem 1965,8(6),807

合成路线图解说明: The reaction of isatoic anhydride (I) with 1-(3-aminopropyl)-4-phenylpiperazine (II) in DMF at 40-60 C gives the o-aminobenzamide derivative (III), which is then cyclized by the action of phosgene in refluxing chlorobenzene.