SGB-1534-药物合成数据库

【药物名称】SGB-1534

化学结构式(Chemical Structure):

参考文献No.	46469
标题:	Phenylpiperazine derivatives
作者:	Nagano, H.; et al. (Chugai Pharmaceutical Co. Ltd.)
来源:	EP 0089065; JP 58159480; US 4578465

合成路线图解说明: This compound can be obtained by two related ways: 1) By cyclization of 1-(2-methoxyphenyl)-4-[2-(2-aminobenzoyl)amino-ethyl]piperazine (I) with trichloromethyl chloroformate, with triethylamine as condensing agent and methylene chloride as solvent. 2) By cyclization of 1-(2-methoxyphenyl)-4-[2-(2-aminobenzoyl)amino-ethyl]piperazine (I) with urea by heating at 180 C in DMF.

参考文献No.	75168
标题:	SGB-1534
作者:	Casta馿r, J.; Serradell, M.N.; Mannhold, R.
来源:	Drugs Fut 1985,10(12),993

合成路线图解说明: This compound can be obtained by two related ways: 1) By cyclization of 1-(2-methoxyphenyl)-4-[2-(2-aminobenzoyl)amino-ethyl]piperazine (I) with trichloromethyl chloroformate, with triethylamine as condensing agent and methylene chloride as solvent. 2) By cyclization of 1-(2-methoxyphenyl)-4-[2-(2-aminobenzoyl)amino-ethyl]piperazine (I) with urea by heating at 180 C in DMF.