S-1389, 711389-S-药物合成数据库

【药物名称】S-1389, 711389-S

化学结构式(Chemical Structure):

参考文献No.	67132
标题:	711389-S
作者:	Ueda, M.
来源:	Drugs Fut 1985,10(6),472

合成路线图解说明: This 1-vinylimidazole compound (II) is obtained by reaction of N,N'-thionyldiimidazole (A) with 2-hydroxy-3,6-dichloroacetophenone (I) in dichloro-methane. Treatment of (II) with epibromohydrin (B) in DMF in the presence of NaH gives the epoxy compound (III), which is then treated with isopropylamine (C) to obtain the propanolamine compound (IV). The hydrochloride can be prepared by treatment of the free base (IV) with one molar equivalent of HCl in AcOEt.

参考文献No.	607705
标题:	Synthesis and antiarrhythmic activity of new 1-[1-[2-[3-(alkylamino)-2-hydroxypropoxy]phenyl]vinyl]-1H-imidazoles and related compounds
作者:	Ogata, M.; Matsumoto, H.; Takahashi, K.; Shimizu, S.; Kida, S.; Ueda, M.; Kimoto, S.; Haruna, M.
来源:	J Med Chem 1984,27(9),1142

合成路线图解说明: This 1-vinylimidazole compound (II) is obtained by reaction of N,N'-thionyldiimidazole (A) with 2-hydroxy-3,6-dichloroacetophenone (I) in dichloro-methane. Treatment of (II) with epibromohydrin (B) in DMF in the presence of NaH gives the epoxy compound (III), which is then treated with isopropylamine (C) to obtain the propanolamine compound (IV). The hydrochloride can be prepared by treatment of the free base (IV) with one molar equivalent of HCl in AcOEt.