Sch-32651-药物合成数据库

【药物名称】Sch-32651

化学结构式(Chemical Structure):

参考文献No.	8685
标题:	Imidazo[1,2-a]pyridines and use
作者:	Bristol, J.A.; Puchalski, C. (Schering Corp.)
来源:	EP 0068378; ES 513431; US 4450164

合成路线图解说明: The cyclization of 2-amino-3-chloropyrazine (I) with chloroacetone (II) by means of triethylamine at 100 C gives 8-chloro-2-methylimidazo[1,2-a]pyrazine (III), which is treated with benzyl alcohol and NaOH in DMF to yield 8-benzyloxy-2-methylimidazo[1,2-a]pyrazine (IV). The nitrosation of (V) with butyl nitrite in refluxing dioxane affords 8-benzyloxy-3-nitroso-2-methylimidazo[1,2-a]pyrazine (V), which is finally reduced with Zn in acetic acid, and treated with HCl.

参考文献No.	67110
标题:	SCH-32651
作者:	Casta馿r, J.; Serradell, M.N.
来源:	Drugs Fut 1985,10(6),474

合成路线图解说明: The cyclization of 2-amino-3-chloropyrazine (I) with chloroacetone (II) by means of triethylamine at 100 C gives 8-chloro-2-methylimidazo[1,2-a]pyrazine (III), which is treated with benzyl alcohol and NaOH in DMF to yield 8-benzyloxy-2-methylimidazo[1,2-a]pyrazine (IV). The nitrosation of (V) with butyl nitrite in refluxing dioxane affords 8-benzyloxy-3-nitroso-2-methylimidazo[1,2-a]pyrazine (V), which is finally reduced with Zn in acetic acid, and treated with HCl.