Rokitamycin, TMS-19-Q DS 200, TMS-19Q, Rokicid, Rokital, Ricamycin-药物合成数据库

【药物名称】Rokitamycin, TMS-19-Q DS 200, TMS-19Q, Rokicid, Rokital, Ricamycin

化学结构式(Chemical Structure):

参考文献No.	49476
标题:	TMS-19Q
作者:	Serradell, M.N.; Casta馿r, J.; Burnie, J, Matthews, R.
来源:	Drugs Fut 1985,10(6),486

合成路线图解说明: Leucomycin A5 (I) is acetylated with acetic anhydride giving the corresponding 2'-O-acetyl derivative (II), which is converted to the 3,9-di-O-trimethylsilyl compound (III) by reaction with trimethylsilyl chloride and pyridine. The reaction of (III) with propionyl chloride and tribenzylamine affords 2'-O-acetyl-17,18-enol-18,3''-di-O-propionyl-3,9-di-O-trimethylsilylleucomycin A5 (IV).

合成路线图解说明: Compound (IV) by treatment with K2CO3 in aqueous methanol is converted to 2'-O-acetyl-3''-O-propionylleucomycin A5 (V). Finally, this compound is hydrolyzed partially with acetic acid.

参考文献No.	605740
标题:	Acyl derivatives of 16-membered macrolides. I. Synthesis and biological properties of 3''-O-propionylleucomycin A5 (TMS-19-Q)
作者:	Sakakibaa, H.; Okekawa, O.; Fujiwara, T.; Otani, M.; Omura, S.
来源:	J Antibiot 1981,34(8),1001

合成路线图解说明: Leucomycin A5 (I) is acetylated with acetic anhydride giving the corresponding 2'-O-acetyl derivative (II), which is converted to the 3,9-di-O-trimethylsilyl compound (III) by reaction with trimethylsilyl chloride and pyridine. The reaction of (III) with propionyl chloride and tribenzylamine affords 2'-O-acetyl-17,18-enol-18,3''-di-O-propionyl-3,9-di-O-trimethylsilylleucomycin A5 (IV).

合成路线图解说明: Compound (IV) by treatment with K2CO3 in aqueous methanol is converted to 2'-O-acetyl-3''-O-propionylleucomycin A5 (V). Finally, this compound is hydrolyzed partially with acetic acid.