Amiprilose, SM-1213, Therafectin-药物合成数据库

【药物名称】Amiprilose, SM-1213, Therafectin

化学结构式(Chemical Structure):

参考文献No.	46012
标题:	Method of enhancing learning and/or memory in warm blooded animals
作者:	Gordon, P. (Boston Life Sciences, Inc.)
来源:	US 3965262

合成路线图解说明: The reaction of 1,2:5.6-di-O-isopropyliden-D-glucofuranose (I) with 3-chloro-N,N-dimethylaminopropane (II) by means of NaOH in refluxing dioxane gives 1,2:5,6-di-O-isopropylidene-3-O-[3'-(N,N-dimethylamino)propyl]-D-gluco-furanose (III), which is partially hydrolyzed with HCl in water.

参考文献No.	65217
标题:	Therafectin
作者:	Hopkins, S.J.; Serradell, M.N.; Casta馿r, J.
来源:	Drugs Fut 1985,10(4),301

合成路线图解说明: The reaction of 1,2:5.6-di-O-isopropyliden-D-glucofuranose (I) with 3-chloro-N,N-dimethylaminopropane (II) by means of NaOH in refluxing dioxane gives 1,2:5,6-di-O-isopropylidene-3-O-[3'-(N,N-dimethylamino)propyl]-D-gluco-furanose (III), which is partially hydrolyzed with HCl in water.