【药物名称】Wy-41770
化学结构式(Chemical Structure):
参考文献No.46013
标题:Method for treating inflammation
作者:Wolf, M. (American Home Products Corp.)
来源:EP 0035903; GB 2071098; JP 82500244; US 4267192
合成路线图解说明:

The Wittig condensation of triethyl phosphonoacetate (II) with 5H-dibenzo[a,d]cyclohepten-5-one (I) by means of NaH in DMSO gives the ethyl (III), which is finally hydrolyzed with KOH in refluxing ethanol.

参考文献No.65199
标题:WY-41770
作者:Serradell, M.N.; Casta馿r, J.; Arrigoni-Martelli, E.
来源:Drugs Fut 1985,10(4),309
合成路线图解说明:

The Wittig condensation of triethyl phosphonoacetate (II) with 5H-dibenzo[a,d]cyclohepten-5-one (I) by means of NaH in DMSO gives the ethyl (III), which is finally hydrolyzed with KOH in refluxing ethanol.

参考文献No.800017
标题:Fulvenes and thermochromic ethylenes. 57. Wittig-Homer reaction with fulvene ketones and related ketones
作者:Bergmann, E.D.; Solomonovici, A.
来源:Synthesis 1970,2(4),183-189
合成路线图解说明:

The Wittig condensation of triethyl phosphonoacetate (II) with 5H-dibenzo[a,d]cyclohepten-5-one (I) by means of NaH in DMSO gives the ethyl (III), which is finally hydrolyzed with KOH in refluxing ethanol.

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