GYKI-32887, RGH-7825-药物合成数据库

【药物名称】GYKI-32887, RGH-7825

化学结构式(Chemical Structure):

参考文献No.	41905
标题:	Novel ergol-8-ene and ergolin compounds and process for preparing same
作者:	Mago, N.K.E.; et al. (Gedeon Richter Ltd.)
来源:	DE 3026271; HU 180467

合成路线图解说明: Elimoclavine (I) obtained by fermentation is first O-mesylated and then the mesyl group in the product (II) displaced by 2-aminoethanol to give the hydroxyethylamino derivative (III). Repeated acylation of (III) with mesyl chloride affords the N,O-dimesylate (IV), which exchanges the O-mesyl group for an azido group on treatment with sodium azide to give the base (VI). Salt formation with maleic acid gives RGH-7825 (1,2).

参考文献No.	71741
标题:	RGH-7825
作者:	N骻r醖i, M.
来源:	Drugs Fut 1985,10(9),753

合成路线图解说明: Elimoclavine (I) obtained by fermentation is first O-mesylated and then the mesyl group in the product (II) displaced by 2-aminoethanol to give the hydroxyethylamino derivative (III). Repeated acylation of (III) with mesyl chloride affords the N,O-dimesylate (IV), which exchanges the O-mesyl group for an azido group on treatment with sodium azide to give the base (VI). Salt formation with maleic acid gives RGH-7825 (1,2).