Nemonapride, Emonapride, YM-09151-2, Emilace-药物合成数据库

【药物名称】Nemonapride, Emonapride, YM-09151-2, Emilace

化学结构式(Chemical Structure):

参考文献No.	47159
标题:	Benzamide derivatives
作者:	Takashima, M.; Iwanami, S.; Usuda, S. (Yamanouchi Pharmaceutical Co., Ltd.)
来源:	BE 0885435; FR 2444461; US 4210660

合成路线图解说明: The reaction of 1-benzyl-2-methyl-3-pyrrolidone (I) with hydroxylamine by means of Na2CO3 in hot ethanol gives the corresponding oxime (II), which is reduced with H2 over Raney-Ni in methanol containing ammonia to afford 1-benzyl-2-methyl-3-aminopyrrotidine (III). Finally, this compound is condensed with 2-methoxy-4-methylamino-5-chlorobenzoic acid (IV) by means of ethyl chlorocarbonate and triethylamine in methylene chloride.

参考文献No.	62067
标题:	YM-09,151-2
作者:	Serradell, M.N.; Casta馿r, J.; Blancafort, P.; Owen, R.T.
来源:	Drugs Fut 1982,7(1),47

合成路线图解说明: The reaction of 1-benzyl-2-methyl-3-pyrrolidone (I) with hydroxylamine by means of Na2CO3 in hot ethanol gives the corresponding oxime (II), which is reduced with H2 over Raney-Ni in methanol containing ammonia to afford 1-benzyl-2-methyl-3-aminopyrrotidine (III). Finally, this compound is condensed with 2-methoxy-4-methylamino-5-chlorobenzoic acid (IV) by means of ethyl chlorocarbonate and triethylamine in methylene chloride.