【药物名称】Brotizolam, WE-941, Lendormine, Lendorm, Lendormin, Ladormin, Indormyl
化学结构式(Chemical Structure):
参考文献No.49498
标题:Inhibitors of histone deacetylase
作者:Delorme, D.; Ruel, R.; Lavoie, R.; Thibault, C.; Abou-Khalil, E. (MethylGene Inc.)
来源:EP 1233958; JP 2003514904; WO 0138322
合成路线图解说明:

A typical pathway for the preparation of the title compound is depicted. Slight modifications are possible according to the patent literature.

合成路线图解说明:

Acylation of 4-iodoaniline (I) with 3,4-dimethoxybenzenesulfonyl chloride (II), followed by basic methanolysis leads to sulfonamide (III). Heck coupling of aryl iodide (III) with acrylic acid (IV) in the presence of tris(dibenzylideneacetone)dipalladium and tri(o-tolyl)phosphine gives the cinnamic acid derivative (V). This is then coupled to the tetrahydropyranyl-protected hydroxylamine (VI) by means of EDC/HOBt to furnish (VII). The tetrahydropyranyl hydroxamate (VII) is finally deprotected under acidic conditions to produce the title compound.

参考文献No.700939
标题:
作者:Coon, M.; Singer, J.; Hollenback, D.; Romero, L.; Pound, J.; Tulinsky, J.; de Vires, P.
来源:C.H. Boehringer Sohn. Investigational Brochure 1976,30(6, Suppl. 1),
合成路线图解说明:

A typical pathway for the preparation of the title compound is depicted. Slight modifications are possible according to the patent literature.

参考文献No.700940
标题:Substituted 6-aryl-4H-S-triazolo-[3,4-c]-thieno-[2,3-e]-1,4-diazepinesand acid addition salts thereof
作者:Weber, K.H.; et al.
来源:CA 1066274; DE 2410030; GB 1490269; ZA 7501246
合成路线图解说明:

A typical pathway for the preparation of the title compound is depicted. Slight modifications are possible according to the patent literature.

参考文献No.700941
标题:Neues Verfahren zur Herstellung von 8-Brom-thieno-triazolo-1,4-diazepin
作者:Weber, K.H.; Bauer, A.; Langbein, A.
来源:DE 2503235; ES 444612; JP 51100096
合成路线图解说明:

A typical pathway for the preparation of the title compound is depicted. Slight modifications are possible according to the patent literature.

参考文献No.700942
标题:Verfahren zur Herstellung von substituierten 6-Ayrl-4H-s-triazolo-[3,4,c]-thieno-[2,3-e]-1,4-diazepinen
作者:Weber, K.H.; Bauer, A.; Langbein, A.
来源:DE 2533924; JP 52017496
合成路线图解说明:

A typical pathway for the preparation of the title compound is depicted. Slight modifications are possible according to the patent literature.

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