Cefpimizole sodium, U-63196E(free acid), AC-1370(free acid), Renilan, Ajicef-药物合成数据库

【药物名称】Cefpimizole sodium, U-63196E(free acid), AC-1370(free acid), Renilan, Ajicef

化学结构式(Chemical Structure):

参考文献No.	46760
标题:	Imidazoledicarboxylic acid substituted cephalosporin derivatives
作者:	Yasuda, N.; Eguchi, C.; Okutsu, M.; Hirose, Y. (Ajinomoto Co., Inc.)
来源:	DE 2826546; FR 2394550; JP 54005974; US 4217450

合成路线图解说明: The reaction of imidazole-4,5-dicarboxylic acid (I) with SOCl2 in refluxing benzene gives the corresponding acid chloride (II), which is condensed with 7-beta-[D-(-)-alpha-aminophenylacetamido]cephalosporanic acid sodium salt (III) by means of triethylamine in dichloromethane to afford 7-beta-[D-(-)-alpha-[4(5)-carboxyimidazole-5(4)-carboxamido]phenyl acetamidolcephalosporanic acid (IV). Finally, this compound is condensed with 4-pyridineethanesulfonic acid (V) by means of NaI in water at 70 C.

参考文献No.	49520
标题:	AC-1370
作者:	Casta馿r, J.; Serradell, M.N.; Blancafort, P.
来源:	Drugs Fut 1982,7(6),373

合成路线图解说明: The reaction of imidazole-4,5-dicarboxylic acid (I) with SOCl2 in refluxing benzene gives the corresponding acid chloride (II), which is condensed with 7-beta-[D-(-)-alpha-aminophenylacetamido]cephalosporanic acid sodium salt (III) by means of triethylamine in dichloromethane to afford 7-beta-[D-(-)-alpha-[4(5)-carboxyimidazole-5(4)-carboxamido]phenyl acetamidolcephalosporanic acid (IV). Finally, this compound is condensed with 4-pyridineethanesulfonic acid (V) by means of NaI in water at 70 C.