【药物名称】Clodronate disodium, KCO-692, Cl2MDP, Lytos, Ostac, Clastoban, Loron, Clasteon, Bonefos
化学结构式(Chemical Structure):
参考文献No.46779
标题:Substituted methylene diphosphonic acids and their salts
作者:Roy, C.H. (The Procter & Gamble Co.)
来源:BE 0672205; DE 1793768; FR 1457272; GB 1026366; US 3404178; US 3422021
合成路线图解说明:

The reaction of dibromomethane (I) with triisopropylphosphite (II) at 145 C gives tetraisopropyl methylenediphosphonate (III), which is treated first with sodium and then with chlorine to give the compound (IV). This compound is finally hydrolyzed with refluxing concentrated HCl, or treated with refluxing tetrachloroethane.

参考文献No.49534
标题:Clodronate disodium
作者:Casta馿r, J.; Hopkins, S.J.; Blancafort, P.; Serradell, M.N.
来源:Drugs Fut 1982,7(9),615
合成路线图解说明:

The reaction of dibromomethane (I) with triisopropylphosphite (II) at 145 C gives tetraisopropyl methylenediphosphonate (III), which is treated first with sodium and then with chlorine to give the compound (IV). This compound is finally hydrolyzed with refluxing concentrated HCl, or treated with refluxing tetrachloroethane.

参考文献No.700834
标题:Substituted methylene diphosphonic acids and their salts
作者:Roy, C.H.
来源:NL 6514133
合成路线图解说明:

The reaction of dibromomethane (I) with triisopropylphosphite (II) at 145 C gives tetraisopropyl methylenediphosphonate (III), which is treated first with sodium and then with chlorine to give the compound (IV). This compound is finally hydrolyzed with refluxing concentrated HCl, or treated with refluxing tetrachloroethane.

参考文献No.800199
标题:Tetrasodium carbonyldiphosphonate. Synthesis reactions and spectral properties
作者:Nicholson, D.A.; Prentice, J.B.; Quimby, O.T.
来源:J Org Chem 1967,32(12),4111-14
合成路线图解说明:

The reaction of dibromomethane (I) with triisopropylphosphite (II) at 145 C gives tetraisopropyl methylenediphosphonate (III), which is treated first with sodium and then with chlorine to give the compound (IV). This compound is finally hydrolyzed with refluxing concentrated HCl, or treated with refluxing tetrachloroethane.

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