ICI-118551-药物合成数据库

【药物名称】ICI-118551

化学结构式(Chemical Structure):

参考文献No.	47236
标题:	Alkanolamine derivs., process for their preparation and pharmaceutical compsns. containing them
作者:	Tucker, H. (AstraZeneca plc)
来源:	EP 0003664

合成路线图解说明: The condensation of 7-methylindan-4-ol (I) with crotyl chloride (II) by means of NaH in DMF gives 1-(7-methylindan-4-yloxy)-trans-2-butuene (III), which is epoxidized with H2O2 in MeCN-MeOH yielding 1-(7-methylindan-4-yloxy)-trans-2,3-epoxybutane (IV). Finally, this compound is treated with isopropylamine (A) in refluxing water.

参考文献No.	60597
标题:	ICI-118,551
作者:	Casta馿r, J.; Blancafort, P.; Weetman, D.F.; Serradell, M.N.
来源:	Drugs Fut 1983,8(10),853

合成路线图解说明: The condensation of 7-methylindan-4-ol (I) with crotyl chloride (II) by means of NaH in DMF gives 1-(7-methylindan-4-yloxy)-trans-2-butuene (III), which is epoxidized with H2O2 in MeCN-MeOH yielding 1-(7-methylindan-4-yloxy)-trans-2,3-epoxybutane (IV). Finally, this compound is treated with isopropylamine (A) in refluxing water.